SupelMIP™ - Analytical SPE Products
SupelMIP™ SPE products are a range of highly selective SPE phases based on molecularly imprinted polymers. They are designed to extract trace levels of analytes or analyte classes from complex biological matrices.
Due to the excellent selectivity of these phases they offer benefits such as: lower detection limits, significant time and cost savings and improved MS compatibility
- Lower detection limits due to cleaner extracts
- Significant time and cost savings due to simplified washing protocols with less sample pre-treatment and extraction fewer steps
- Improved MS compatibility due to that interfering substances can be washed away under harsher washing conditions resulting in minimized matrix effects and minimized or eliminated ion suppression
MIP Technologies has an exclusive global distribution agreement with Supelco, a division of Sigma-Aldrich for the distribution of SupelMIP products.
www.sigmaaldrich.com/supelmip
SupelMIP™ products are offered in a standard 3 or 10-ml off-line SPE format, but other SPE and 96-well formats can be requested. All products are delivered with a data sheet, describing the extraction methodology in detail, and a quality assurance report.
Literature
Selective Extractions by Molecularly Imprinted Polymers (MIPs). The Column, Feb 2006
Analysis of analytes - The use of MIP´s in solid-phase extraction increases efficiency and improves detection limits. Laboratory News, June 2006
Molecularly Imprinted Polymers: A New Generation of Affinity Matrices. American Laboratory, Oct 2006
SupelMIP™ Clenbuterol
A specific SPE sorbent optimised for extraction of clenbuterol from biological samples
Clenbuterol is extracted with a high recovery. Due to the selectivity this extraction method enables determination at a limit of quantitation of 0.5 ng/ml using the economically favourable detection system; HPLC-UV.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53201-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ Beta-agonist
A class selective SPE sorbent for multi-residue extraction of Beta-agonists in urine or tissue samples
A broad spectrum of Beta-agonists in biological samples can be extracted with the SupelMIP™ Beta-agonist product e.g. brombuterol, clenbuterol, formoterol, isoxuprine, mapenterol, ractopamine, ritodrine, salbutamol, salmeterol, terbutaline, tulobuterol, zilpaterol and others.
Detection limits are consistent with a reliable survey of drugs of abuse. The MIP columns have a superior loading capacity compared to immuno-affinity columns. It is recommended to use MS detection for results with forensic validity. It is also possible to use the SupelMIP™ Beta-agononist columns in automated solid-phase extraction systems.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53225-U | 25 mg | 3 ml | 50 | www.sigmaaldrich.com |
| 53202-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ NNAL
A specific SPE sorbent for extraction of the tobacco-specific nitrosamine metabolite NNAL, in biological samples
With this sorbent NNAL can be selectively extracted from biological samples with high recoveries. Compared to current analytical methods for accurate NNAL detection, which are elaborate and time-consuming, SupelMIP™ NNAL gives reliable and accurate results and reduces the sample handling significantly. It allows extremely low limits of quantitation and has been shown to be highly reproducible. It can also be used for quantitation of NNAL where nicotine is present.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53203-U | 25 mg | 3 ml | 50 | www.sigmaaldrich.com |
| 53206-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ Riboflavin (Vitamin B2)
A specific SPE sorbent for extraction of Riboflavin from aqueous samples
This sorbent allows Riboflavin to be selectively extracted from solution with high recoveries (up to 85%) and without co-extracting other vitamins.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53207-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ Triazine10
A SPE sorbent for multi-residue extraction of triazines and triazine metabolites in water, soil and food products
The SupelMIP™ Triazine10 shows excellent selectivity towards the following triazines and triazine metabolites: atrazine, simazine, propazine, cyanazine, sebutylazine, deisopropylatrazine, deethylatrazine, deethylterbutylazine, prometon and hydroxyterbutylazine. Extraction recoveries are reproducible and in the range 80-95%.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53208-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ Chloramphenicol
A specific SPE sorbent for extraction of the banned (European Union) antibiotic Chloramphenicol from biological matrices
By using this SPE phase, residues of Chloramphenicol can be extracted efficiently and rapidly, improving considerably on existing extraction methods. Furthermore, detection limits well below the minimum required performance limit (MRPL) for Chloramphenicol are achieved, enhancing the reliability of the detection and ensuring improved food safety and quality. Furthermore the sample handling time is reduced significantly compared with conventional methods.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53209-U | 25 mg | 3 ml | 50 | www.sigmaaldrich.com |
| 53210-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ Beta Blocker
A class selective SPE sorbent for multi-residue extraction of Beta blockers in water and biological samples
A broad spectrum of Beta-blockers in biological samples can be extracted with the SupelMIP™ Beta Blocker product e.g. atenolol, betaxolol, carazolol, pindolol, propranolol, sotalolol, timolol, metoprolol and others.
Detection limits are consistent with a reliable survey of drugs of abuse. The MIP columns have a superior loading capacity compared to immuno-affinity columns. It is recommended to use MS detection for results with forensic validity. It is also possible to use the SupelMIP™ Beta blocker columns in automated solid-phase extraction systems.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53213-U | 25 mg | 3 ml | 50 | www.sigmaaldrich.com |
| 53218-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ TSNAs
A class selective SPE sorbent for multi-residue extraction of 4 different Tobacco specific Nitrosamines: NNK, NNN, NAB and NAT
With this sorbent the 4 different Tobacco specific Nitrosamines can be selectively extracted from biological samples with high recoveries. Compared to current analytical methods for accurate TSNA detection, which are elaborate and time-consuming, SupelMIP™ TSNAs gives reliable and accurate results and reduces the sample handling significantly. It allows low limits of quantitation and has been shown to be highly reproducible.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53222-U | 25 mg | 3 ml | 50 | www.sigmaaldrich.com |
| 53221-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ Full Beta Receptor (beta agonists and beta blockers)
A class selective SPE sorbent for simultaneous multi-residue extraction of beta agonists and beta blockers in water and biological samples
A broad spectrum of beta agonists and beta blockers in biological samples can be extracted with the SupelMIP™ Full Beta Receptor product.
Detection limits are consistent with a reliable survey of drugs of abuse. The MIP columns have a superior loading capacity compared to immuno-affinity columns. It is recommended to use MS detection for results with forensic validity. It is also possible to use the SupelMIP™ Full Beta Receptor cartridges in automated solid-phase extraction systems.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53224-U | 25 mg | 3 ml | 50 | www.sigmaaldrich.com |
| 53223-U | 25 mg | 10 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ Amphetamines
A Class-selective SPE sorbent for extraction of amphetamine related drugs (Amphetamine, Methamphetamine, Phentermine, MDA, MDMA and MDEA) from biological samples e.g. urine and saliva
Amphetamine related drugs are currently among the most well-known psychotropic drugs of abuse and are used in sport, in the workplace and by recreational users. For, clinical and doping control SupelMIP™ SPE-Amphetamine drugs provide a simple, fast and class selective solid-phase extraction (SPE) procedure.The high senstivity of the SPE method using this product makes it particularly useful in forensic applications where low level detection may be required.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 53228-U | 25 mg | 3 ml | 50 | www.sigmaaldrich.com |
SupelMIP™ Fluoroquinolones
A Class-selective SPE sorbent for extraction of fluoroquinolones (FQLs) from food samples e.g. kidney, milk and honey
FQL's comprise a group of broad-spectrum antibacterial agents which are widely used in human medicine and to treat infections in farmed fish, shrimp, turkeys, pigs, calves and poultry. The presence of this antibiotic class in the environment at sub-therapeutic levels can lead to multiple FQL-resistant bacterial strains. When used to treat animals, FQLs may end up in the human food chain causing allergic reactions while at the same time encouraging development of resistant bacteria. Monitoring these substance residues at trace levels is therefore regulated by law. The EU has set strict Maximum Residue Limits (MRL's), the values of which depend on the particular compound and matrix, e.g. the MRL for enrofloxacin in bovine kidney is set at 200µg/kg. The US, Canada and Japan have also set MRL's but for a more limited range of quinolones.
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| Code | Sorbent mass | Column volume | Columns/box | Order |
| 25 mg | 3 ml | 50 | Enquire |
