SupelMIP™ Full Beta Receptor

- A class selective SPE sorbent for multi-residue extraction of beta agonists and beta-blockers in waters and biological samples.

Background

A broad spectrum of beta agonists and beta blockers in biological samples can be extracted with the SupelMIP™ Full Beta Receptor product.

Detection limits are consistent with a reliable survey of drugs of abuse. The SupelMIP Cartridges have a superior loading capacity compared to immuno-affinity columns. It is recommended to use MS detection for results with forensic validity. It is also possible to use the SupelMIP™ Full Beta Receptor cartridges in automated solid-phase extraction systems.

Beta blockers, also called beta receptor antagonists, are an important class of anti-hypertensive and cardio arrhythmic drugs. For clinical, veterinary and environmental monitoring a highly selective and sensitive method for the simultaneous determination of several beta blockers is required. Using the SupelMIP™ Beta Blocker MIP an easy, effective and selective extraction of the beta blocker class is obtained.

Features and applications

At extremely low limits of detection and quantification a broad spectrum of beta agonists and beta blockers in biological samples can be extracted with the SupelMIP™ Full Beta Receptor product.

Using the molecularly imprinted SPE, the extraction procedure is considerably simplified so that simultaneous quantitation of beta agonists and beta blockers is faster, more robust and at ultimately lower cost. There is little or no loss of sensitivity in LC-MS/MS due to ion suppression and contamination of the interface.

It is also possible to use the SupelMIP™ Full Beta Receptor cartridge in automated solid-phase extraction systems. Application notes for simultaneous extraction of beta agonists and beta-blockers from water and horse urine samples with LC-MS detection are available.

More information about SupelMIP™ Full Beta Receptor product can be found in the Product Bulletin.
Recoveries together with chromatograms and the SPE procedure are given in the Data Sheet.

Code	Sorbent mass	Column volume	Columns/box	Order
53224-U	25 mg	3 ml	50	www.sigmaaldrich.com
53223-U	25 mg	10 ml	50	www.sigmaaldrich.com