Methodology

High Performance Molecular Imprinting

Thin-layer MIPs
Gives higher surface areas and improved mass transfer
With its new proprietary technology known as ‘Grafting’, in which MIPs are directed to the surface of porous silica particles, MIP Technologies can produce solid phase materials that have large surface areas (up to 1000m² per gram) and improved mass transfer properties. This is particularly important where separation of similar molecules (eg enantiomers) is required or fast kinetic resolution is desirable.

Surface imprinted MIPs
Suitable for larger molecules
MIP Technologies holds patents in the area of hierarchical imprinting, where the template is immobilized onto a support material during polymerization, whereafter the support is removed. The thereby polymers obtained now have binding sites that are highly accessible to molecules that are much larger than the imprinted template. This is particularly relevant to epitope imprinting of proteins and similar applications. As depicted in the figure, a fragment of the target is sufficient to form a specific cavity into which the whole molecule (eg. protein or peptide) can than bind.