Welcome to the last issue of MIP Technologies Newsletter before the summer break. The next issue is scheduled for September.

In this issue of the Newsletter you can read about trace level determination of beta-blockers in natural water. This new MIP for Beta-blockers also works well for plasma and urine samples. Application notes for all three matrices can be downloaded from our web-site. Do not forget to order your free test cartridges. You can do that easily, directly via this Newsletter.

MIP Technologies was present at the 5th International Symposium on Hormone and Veterinary Drug Residue Analysis (HVDRA) in Antwerp, Belgium and we have summarized here some posters showing MIPs for solid-phase extraction for Beta-agonists, Fluoroquinolone antibiotics and Sulphonamides.

In this issue you can also read an article about 'selectivity' in the imprinting of small molecules.

I hope you will enjoy reading the contributions and wish you all a very nice summer!

Christine Widstrand
VP Sales & Marketing
MIP Technologies AB

Beta-blockers are an important class of anti-hypertensive drugs. With their growing use the contamination of environmental waters with beta-blockers has increased. Therefore a highly selective and sensitive method for the simultaneous determination of beta-blockers in water is required. Such a method based on a class selective MIP extraction for, atenolol, betaxolol, carazolol, pindolol, propranolol, sotalol, timolol and metoprolol was developed by Prof. Damià Barceló et al at the Department of Environmental Chemistry, IIQAB-CSIC, Barcelona, Spain. The extraction protocol developed offers both good efficiency and selectivity in the extraction of the selected beta-blockers from environmental water samples. Recoveries achieved were higher than 80%. LODs obtained for the beta-blockers investigated were in all instances lower than 6 pg (instrumental LOD), which is equivalent to 3 ng/L in water.
 Read more (.pdf) Poster "Trace level determination of Beta-blcokers in natural water" by Pizzolato et al.

The Dutch National Institute for Public Health and the Environment - RIVM showed the poster "Screening of Beta-agonists in bovine hair using molecular imprinted polymers (MIPs) and LCMSn." and the Swedish National Food Institue presented the poster "Analysis of beta-agonists in liver and urine using molecular imprinted polymers and LC-MS/MS".
Both posters showed validation studies for Beta-agonists according to Commission Decision 2002/657/EC.
 Read more (.pdf) "Screening of Beta-agonists in bovine hair" by Wubs et al.
 Read more (.pdf) "Analysis of Beta-agonist in liver and urine" by Söderlund et al.

At the symposium there were also two posters presented by Applied Molecular Receptor Group, Dept. of Biological Organic Chemistry, IIQAB, (CSIC), Barcelon, Spain. With the titels "Novel and improved analytical procedures based on molecularly imprinted polymers for fluoroquinolone antibiotics" and "Sulphonamide molecularly imprinted polymers as stationary solid phase for selective chromatography and selective solid phase extraction"
 Read more (.pdf) "Molecularly imprinted polymers for fluoroquinolone antibiotics" by Álamo et al.
 Read more (.pdf) "Sulphonamide molecularly imprinted polymers" by Obregón

A number of conditions will directly influence the synthesis of new MIPs. Above all, the technique relies on the successful stabilization of individually weak interactions between the template and the functional monomers. Stable monomer-template assemblies will in turn lead to a useful concentration of high affinity binding sites in the resulting polymers. The guiding principles in this binding site design are the same which govern molecular recognition in biological systems as well as in low molecular weight receptors: Functional group complementarity, multiple converging interactions and stiffness of the pendent groups and the template.
 Read more (.pdf) Written by Prof. Börje Sellergren, Dortmund University

Contents

• Trace level determination of Beta-blockers in natural water
• MIP presentations at the 5^th International symposium HVDRA
• Factors influencing the selectivity and the recognition factors of MIPs

MIP for Beta-blocker
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Download application notes for extraction of Beta-blockers from water, plasma and urine from our web-site
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Upcoming Meeting
MIP2006
10th - 14th September 2006
Cardiff, UK
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MIP Technologies is an innovative biotechnology company working at the boundary of chemistry and materials science. The company is a pioneer in the commercial applications of molecularly imprinted polymers (MIPs), holds important patents and maintains cutting edge research activities in the area. The company's mission is to provide innovative products based on molecularly imprinted polymers that serve industry's needs in analytical, preparative and process scale selective separations.
www.miptechnologies.com