Welcome to issue #7 of MIP Technologies Newsletter.

In this issue we are happy to present a new SupelMIP SPE product, selective for amphetamine and related drugs. The use of this product results in a simple, fast and group selective extraction, suitable for trace level determinations in forensic, toxicological and pharmaceutical applications. We are also presenting a comparison of the SupelMIP SPE-Beta-agonist and mixed-mode SPE for the extraction of beta-agonist from urine samples as well as a comparison on Chloramphenicol extraction using a SupelMIP SPE cartridge and a conventional hydrophilic polymer phase.

We are also happy to provide you with references to new peer-reviewed SupelMIP publications for Chloramphenicol and Beta blockers.

MIP Technologies will be present at ExTech in January and at The 4th International Workshop LC-MS-MS in February. Don't miss the opportunity to meet us there if you will be visiting any of these events.

I hope you will enjoy the reading!

Christine Widstrand
Chief Business Officer
MIP Technologies AB

MIP Technologies has developed a new selective phase for the extraction of amphetamine and related drugs. The SPE method has been evaluated for amphetamine, methamphetamine, phentermine, MDA, MDMA and MDEA and improves detection limits up to one hundred times compared with existing SPE phases on the market.

A rapidly developing technology that obviates the need for multiple clean-up and extraction steps, thereby simplifying the pre-treatment procedure, is solid-phase extraction phases based on molecularly imprinted polymers (MIPs). The use of MIPs has led to simplified sample clean-up, in addition to alowing lower limits of detection and improved MS compatibility, e.g. minimized ion suppression, and significantly reduced analytical costs. Using the SupelMIP™ SPE-Amphetamine resulted in a simple, fast and selective method for the group of amphetamine related drugs tested. Furthermore the recoveries were high and the presence of interfering compounds in the final extract was low. The clean extraction also results in less need for instrument maintenance.

SupelMIP™ SPE cartridges are availabe from Supelco/Sigma-Aldrich  Sigma-Aldrich Technical Report
 Press-release (.pdf)

The Veterinary Institute in Oldenburg in Germany has made a comparison of sample clean up of beta-agonists from urine samples using SupelMIP™SPE Beta-agonist and a conventional mixed-mode SPE. Their conclusions are that SupelMIP SPE Beta-agonist is highly specific for beta-agonists, gives significantly less interfering compounds in the extract compared to conventional mixed-mode SPE and a much higher signal/noise ratio as well as a lower detection limit.
 Read more (.pdf)

Supelco has published an article on the selective extraction of Chloramphenicol using SupelMIP SPE. In this study, an extraction method using a SupelMIP SPE phase was compared against a published method using a conventional hydrophilic SPE phase. The SupelMIP SPE approach provided simpler methodology and significant increases in selectivity relative to the described conventional hydrophilic polymer SPE method. Both points are particularly advantageous where trace detection limits and routine analysis are required.
 Read more (.pdf)

Chloramphenicol
Written by Nestlé Research Centre, Switzerland
"Advantages of Molecularly Imprinted Polymers LC-ESI-MS/MS for the Selective Extraction and Quantification of Chloramphenicol in Milk-Based Matrixes. Comparison with a Classical Sample Preparation" Mohamed et al. Anal. Chem. 79(24), 9557-9565 (2007)

"Development of an improved method method for trace analysis of chloramphenicol using molecularly imprinted polymers" Boyd et al. J. Chromatogr. A, 1174, 63-71 (2007)

Beta Blockers
Written by Environmental Chemistry, IIQAB-CSIC, Spain
"Trace level determination of beta-blockers in natural waters by highly selective molecular imprinted polymers (MIP) followed by liquid chromatography-tandem mass spectrometry quadrupole-linear ion trap (Qq-LIT) mass spectrometry" Gros et al., J. Chromatogr. A (2007), in press (available on-line)

Contents

• Launch of a new SupelMIP™ for the selective extraction of amphetamine and related drugs
• Comparison of SupelMIP™ Beta-agonists and mixed-mode SPE for the extraction of beta-agonists from urine samples
• Selective extraction of Chloramphenicol using SupelMIP™ SPE
• New reviewed publications on SupelMIPs

Meet us at ExTech 2008 (10th International Symposium on Advances in Extraction Techniques 2008), Jan 28-30 Bruges, Belgium

Oral presentation by Börje Sellergren "MIPs as tailored sorbents for molecular recognition based SPE " Tuesday, January 29th 2008, 10:10 L07-03

MIP Technologies poster presentation "Selective SPE for Beta agonists, Beta Blockers and Chloramphenicol using SupelMIPs"

We will exhibit together with Supelco/Sigma-Aldrich

 Read more (external link)
 Register here if you want to book a meeting with us!

Meet us at 4th International Workshop LC-MS-MS 2008, Feb 7-8, Barcelona, Spain

 Read more (external link)
 Register here if you want to book a meeting with us!

MIP Technologies is a world leading company in the development of molecularly imprinted polymers (MIPs). The Company is a pioneer in the commercial applications of MIPs, holds important patents and maintains cutting edge research activities in the area. The Company's mission is to provide innovative products based on molecularly imprinted polymers that serve industry's needs in analytical, preparative and process scale 'selective separations'. The Company has environmental permission to produce MIP phases at the 500 kg level and is well placed to develop large scale separation solutions for its customers. Currently the Company markets and sell analytical separation products (e.g. SPE) via Sigma-Aldrich and has multiple custom process scale projects in place with several blue chip companies. MIP Technologies has its headquarters in Lund, Sweden.
www.miptechnologies.com