Resin Development Service

Development of Custom Designed Selective Resins By MIP Technologies Brochure » 

In the resin development process we work closely with you to engineer a resin that will meet demanding separation or extraction challenges. A project is divided into three major phases.

1. Discovery

We find out if we already have a resin that solves your problem or if we need to develop a new custom resin.

2. Optimization

A candidate resin is thoroughly tested and optimized to solve your separation problem the best way possible.

3. Scale-up and Production

When a candidate resin is optimized to best performance we scale-up and supply you with the amount required.

 

discovery-phase

Phase 1: Discovery

Your separation problem is analyzed and candidate resins are selected from our resin library and evaluated in a screening procedure following conditions that mimic the actual separation problem.

For many applications, suitable resins are already present in our resin library. If no satisfactory hit is identified, new resins are designed. The outcome of the discovery phase is a prototype resin that may be used as is and proceeded to scale-up and production phase directly or further optimized in the optimization phase.

Typical duration: 0.5–4 months.

Phase 2: Optimization

In the optimization phase, the binding properties of the prototype resin are optimized. In particular for industrial applications, further development of the resin is desirable to improve performance, by optimizing particle size, dispersity, surface chemistry, porosity and other properties. Statistical DoE (design-of-experiments) methods are employed at this stage of the development process. The separation or extraction methodology may also be adapted to the desired process.

  • The optimization phase results in a powerful separation material with the ability to very selectively remove a contaminant from the main product.
  • The resin optimization is iterated, gradually improving the performance of the separation material. The final resin performs considerably better than the first generation material and outperforms benchmark resins.
  • Outcome of a Design of Experiment. By varying different synthetic factors during polymer synthesis, the responses (eg the selectivity of the final adsorbent) differ accordingly.
  • Contour plots or response surface plots of an DoE outcome. By selecting the optimal proportions of synthetic parameters, the “sweet spot” of the synthesis is determined.
  • In a favorable chromatographic separation, the contamination is retarded in the resin and eluted after the product has passed through.

Typical duration: 0–4 months.

Phase 3: Scale-up and Production

When a resin candidate with acceptable performance is established, the resin process is scaled up to enable production at the desired scale, ranging from grams to tonnes. During this process the performance of the material is carefully monitored to be maintained throughout the scale-up. A washing procedure able to reach the agreed limits is developed in parallel.

Scale-up starts with producing materials in our in-house state-of-the art ISO certified pilot production plant. The final specifications are established in discussion with you to meet regulatory requirements.

When the resin is ready to roll out into production process, volumes up to the ton scale may be produced. We take responsibility for the production and quality assurance of the final product which may be supplied as bulk material or packed into chromatographic columns with volumes up to 10 L.

Typical duration: 0.5–4 months.

Close Collaboration

We keep a close collaboration with you throughout the process. The performances of candidate materials are presented to you for discussion, and samples are supplied for evaluation after each milestone.

At the end of every phase there is a go/no-go decision point. We deliver a report and an agreed amount of resin for testing and confirmation at the your site. Upon agreement in those meetings, the project will be repeated, terminated or proceeded to the next phase.

Quality assurance

We work under stringent quality conditions. Our well equipped QC laboratories ensure high product quality and low batch-to-batch variations. Physical and chemical characteristics as well as performance and cleanliness of the resins are carefully checked and reported with each batch supplied.

Support and Confidentiality

We employ a strict confidentiality arrangement with you and always offer close support. Contact our highly qualified staff about your demanding extractions or separations and let us propose a potential solution.

Wide Range of Applications

Our process materials can be engineered for an essentially unlimited variety of small and oligomeric molecules. The selectivity can be tuned towards specific molecules or classes of chemically related molecules. Examples of application areas:

  • Pharmaceuticals
  • Food & Beverage Ingredients
  • Chemicals
  • Consumer products
  • Environmental Contaminants

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